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Article

Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring.

European journal of pediatrics - 1 Oct 2021

Qin Jiabi, Li Jinqi, Li Fang, Sun Mengting, Wang Tingting, Diao Jingyi, Zhang Senmao, Luo Liu, Li Yihuan, Chen Letao, Huang Peng, Zhu Ping

Abstract excerpt

Although it is generally recognized that genetic and environmental factors are associated with the risk of congenital heart disease (CHD), the mechanism remains largely uncertain. This study aimed to investigate the association of maternal folate use, the time when folate use was started, and polymorphisms of the reduced folate carrier (RFC1) gene with the risk of CHD in offspring of Chinese descent, which can...

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Identifiers

PMID: 33913025
DOI: 10.1007/s00431-021-04087-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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