Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation.

Journal of virology - 15 May 2018

Peng Wenjie, Bouwman Kim M, McBride Ryan, Grant Oliver C, Woods Robert J, Verheije Monique H, Paulson James C, de Vries Robert P

Abstract excerpt

All human influenza pandemics have originated from avian influenza viruses. Although multiple changes are needed for an avian virus to be able to transmit between humans, binding to human-type receptors is essential. Several research groups have reported mutations in H5N1 viruses that exhibit specificity for human-type receptors and promote respiratory droplet transmission between ferrets. Upon detailed analysis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemagglutinin Glycoproteins, Influenza Virus
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza A Virus, H5N1 Subtype

Share to Receptors, Virus

Share to Sialic Acids

Share to Trachea

Share to Virus Attachment

Source

Open in PubMed Open full text

Identifiers

PMID: 29491160
DOI: 10.1128/JVI.02016-17
PMCID: PMC5923085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation.PMID 29491160Read ↗

A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in FerretsSemantic proximity Read ↗

Receptor binding by a ferret-transmissible H5 avian influenza virus.Semantic proximity Read ↗

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferretsSemantic proximity Read ↗

H7N9 influenza viruses are transmissible in ferrets by respiratory droplet.Semantic proximity Read ↗

A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.Semantic proximity Read ↗

Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model FerretsSemantic proximity Read ↗

Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus.Semantic proximity Read ↗

Three mutations switch H7N9 influenza to human-type receptor specificity.Semantic proximity Read ↗

Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza virusesSemantic proximity Read ↗

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity.Semantic proximity Read ↗

Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.Semantic proximity Read ↗

The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.