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Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome

1 Apr 2025

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) is a hallmark of DNA mismatch repair (MMR) deficiency that leads to genomic instability and increased cancer risk. The tumor microenvironment (TME) significantly influences MSI-driven tumorigenesis, and emerging evidence points to a critical role of the microbiome in shaping this complex interplay. METHODS: This review comprehensively examines the existing literature...

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PMID: 40231893
DOI: 10.1002/cam4.70603

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