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Article

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

18 Sept 2018

Abstract excerpt

Abstract The presence of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue has been associated with microsatellite instability (MSI), lower-level T-cell infiltrates, and poor clinical outcomes. Considering differences in the tumor–immune microenvironment between MSI-high and non–MSI-high carcinomas, we hypothesized that the association of F. nucleatum with immune response might differ by tumor...

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PMID: 30228205
DOI: 10.1158/2326-6066.cir-18-0174

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