Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers.

doi:10.1038/s41598-025-97409-1

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Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers.

Scientific reports - 14 Apr 2025

Ozsahin Ilker, Wang Xiuyuan, Zhou Liangdong, Xi Ke, Hojjati Seyed Hani, Tanzi Emily, Maloney Thomas, Fung Edward K, Dyke Jonathan P, Chen Kewei, Pahlajani Silky, McIntire Laura Beth, Costa Ana Paula, Dartora William Jones, Razlighi Qolamreza R, Glodzik Lidia, Li Yi, Chiang Gloria C, Rusinek Henry, de Leon Mony J, Butler Tracy A

Abstract excerpt

Choroid plexus (CP), best known for producing CSF, also regulate inflammation and clear metabolic waste to maintain brain homeostasis. CP dysfunction is implicated in Alzheimer's Disease (AD), with MRI studies showing CP enlargement in AD. The basis for CP enlargement is unknown. We hypothesized that calcium deposition within CP, which increases with aging and in certain neurodegenerative conditions, might...

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PMID: 40229453
DOI: 10.1038/s41598-025-97409-1
PMCID: PMC11997051

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APOE

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