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A Phenome-Wide association study (PheWAS) of genetic risk for C-reactive protein in children of European Ancestry: Results from the ABCD study.

Brain, behavior, and immunity - 1 Aug 2025

Norton Sara A, Gorelik Aaron J, Paul Sarah E, Johnson Emma C, Baranger David Aa, Siudzinski Jayne L, Li Zhaolong Adrian, Bondy Erin, Modi Hailey, Karcher Nicole R, Hershey Tamara, Hatoum Alexander S, Agrawal Arpana, Bogdan Ryan

Abstract excerpt

BACKGROUND: C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that is associated with adverse physical and mental health outcomes. Identifying factors associated with genetic liability to elevated CRP in childhood may inform our understanding of variability in CRP that could be targeted to prevent and/or delay the onset of related health outcomes. METHODS: We conducted a...

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PMID: 40228565
DOI: 10.1016/j.bbi.2025.04.012
PMCID: PMC12264583

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CRP

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