Article
Transient expression of the diseased phenotype of osteoarthritic chondrocytes in engineered cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Apr 2017
Silverstein Amy M, Stoker Aaron M, Ateshian Gerard A, Bulinski J Chloe, Cook James L, Hung Clark T
Abstract excerpt
Due to the degradation of osteoarthritic (OA) cartilage in post-traumatic OA (PTOA), these tissues are challenging to study and manipulate in vitro. In this study, chondrocytes isolated from either PTOA (meniscal-release (MR) model) or normal (contralateral limb) cartilage of canine knee joints were used to form micropellets to assess the maintenance of the OA chondrocyte phenotype in vitro. Media samples from...
Topics
- Animals
- Cartilage
- Cells, Cultured
- Chondrocytes
- Disease Progression
- Dogs
- Extremities
- Female
- Gene Expression Regulation
- Immunohistochemistry
- Interleukin-8
- Joints
- Male
- Matrix Metalloproteinase 1