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Multi-omics profiling of acute Pseudomonas aeruginosa pneumonia unmasks conventional NK cell depletion and stage-specific therapeutic targets

11 Apr 2025

Abstract excerpt

Pseudomonas aeruginosa (PA) is a key pathogen in hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), challenging clinical medicine. This study aims to elucidate the characteristics of the host’s innate immune response following inhalational PA infection. We developed a mouse model by aerosolized intratracheal inoculation with PA and conducted a comprehensive analysis at the protein,...

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PMID: 40216004
DOI: 10.1080/21505594.2025.2490206

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