Article
Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study.
Neurobiology of aging - 1 Oct 2014
van Doormaal Perry T C, Ticozzi Nicola, Gellera Cinzia, Ratti Antonia, Taroni Franco, Chiò Adriano, Calvo Andrea, Mora Gabriele, Restagno Gabriella, Traynor Bryan J, Birve Anna, Lemmens Robin, van Es Michael A, Saris Christiaan G J, Blauw Hylke M, van Vught Paul W J, Groen Ewout J N, Corrado Lucia, Mazzini Letizia, Del Bo Roberto, Corti Stefania, Waibel Stefan, Meyer Thomas, Ludolph Albert C, Goris An, van Damme Philip, Robberecht Wim, Shatunov Aleksey, Fogh Isabella, Andersen Peter M, D'Alfonso Sandra, Hardiman Orla, Cronin Simon, Rujescu Dan, Al-Chalabi Ammar, Landers John E, Silani Vincenzo, van den Berg Leonard H, Veldink Jan H
Abstract excerpt
Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We...
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