Association of UNC13A with increased amyotrophic lateral sclerosis risk, bulbar onset, and lower motor neuron involvement in a Norwegian ALS cohort.

doi:10.1080/21678421.2024.2447922

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Article

Association of UNC13A with increased amyotrophic lateral sclerosis risk, bulbar onset, and lower motor neuron involvement in a Norwegian ALS cohort.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2025

Novy Camilla, Tysnes Ole-Bjørn, Busk Øyvind L, Jaioun Keson, Holmøy Trygve, Holla Øystein L, Høyer Helle

Abstract excerpt

Objective: Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease characterized by the loss of motor neurons, has limited treatment options available. Treatments targeting specific ALS genes, including UNC13A, have attracted considerable attention. The UNC13A rs12608932 variant has been associated with an increased risk of ALS, shorter survival, and more frequent bulbar onset. Methods: In...

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PMID: 40135631
DOI: 10.1080/21678421.2024.2447922

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UNC13A

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