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Article

Comparative Genomic Characterization of Small Cell Carcinoma of the Bladder Compared With Urothelial Carcinoma and Small Cell Lung Carcinoma.

JCO precision oncology - 1 Apr 2025

Jaime-Casas Salvador, Chawla Neal S, Salgia Nicholas J, Mercier Benjamin, Govindarajan Ameish, Li Xiaochen, Castro Daniela V, Ebrahimi Hedyeh, Barragan-Carrillo Regina, Zang Peter D, LeVee Alexis, Zugman Miguel, Dizman Nazli, Hsu JoAnn, Meza Luis, Zengin Zeynep, Chehrazi-Raffle Alexander, Dorff Tanya, Pal Sumanta K, Tripathi Abhishek

Abstract excerpt

PURPOSE: Small cell bladder cancer (SCBC) is a rare histologic variant of bladder cancer with an aggressive disease course and poor outcomes. Given its uncommon nature, there is a paucity of high-quality data characterizing genomic drivers of this disease, and most patients are treated with approaches mirroring small cell lung cancer (SCLC). Leveraging the Tempus Lens deidentified clinically annotated genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40209138
DOI: 10.1200/PO-24-00947
PMCID: PMC13353030

Genes

RB1
TP53
TERT
ALK
ARID1A
CREBBP
ERBB2
KDM6A
KMT2D
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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