Article
Identification of potential biomarkers and novel therapeutic targets through genomic analysis of small cell bladder carcinoma and associated clinical outcomes.
Urologic oncology - 1 Aug 2022
Burgess Earle F, Sanders J Alexa, Livasy Chad, Symanowski James, Gatalica Zoran, Steuerwald Nury M, Arguello David, Brouwer Cory R, Korn W Michael, Grigg Claud M, Zhu Jason, Matulay Justin T, Clark Peter E, Heath Elisabeth I, Raghavan Derek
Abstract excerpt
OBJECTIVES: Small cell bladder carcinoma (SCBC) represents a rare histologic variant with a poor prognosis and for which no routine biomarkers exist. Limited reports of genomic sequencing in SCBC have demonstrated a high prevalence of TP53 and RB1 gene mutations, though the prognostic value of these and other gene variants in SCBC remains undefined. In this study, we performed targeted genomic sequencing on a...
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