Article
A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors.
Oncology reports - 1 Feb 2016
Zou Yang, Deng Wei, Wang Feng, Yu Xiao-Hong, Liu Fa-Ying, Yang Bi-Cheng, Huang Mei-Zhen, Guo Jiu-Bai, Xie Qiu-Hua, He Ming, Huang Ou-Ping
Abstract excerpt
A recent exome-sequencing study revealed prevalent mitogen-activated protein kinase 1 (MAPK1) p.E322K mutation in cervical carcinoma. It remains largely unknown whether ovarian carcinomas also harbor MAPK1 mutations. As paralogous gene mutations co‑occur frequently in human malignancies, we analyzed here a total of 263 ovarian carcinomas for the presence of MAPK1 and paralogous MAPK3 mutations by DNA sequencing....
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