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Article

In vivo differentiation and genomic evolution in adult male germ cell tumors

17 Oct 2007

Abstract excerpt

Germ cell tumors (GCTs) are the most common solid malignancy in young adult men, but the genes and genomic regions involved in their etiology are not fully defined. We report here an investigation of DNA copy number changes in GCTs using 1 Mb BAC arrays. As expected, 12p gain was the defining genomic alteration, occurring in 72/74 GCTs. Parallel expression profiling of these tumors identified potential oncogenes...

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PMID: 17943972
DOI: 10.1002/gcc.20504

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