Article
AI discovery of TLR agonist-driven phenotypes reveals unique features of peripheral cells from healthy donors and ART-suppressed people living with HIV.
Frontiers in immunology - 1 Jan 2025
Omange Robert Were, Kim Samuel C, Kolhatkar Nikita S, Plott Tempest, Van Trump Will, Zhang Kenneth, O'Donnell Hope, Chen Daniel, Hosny Ahmed, Wiest Michael, Barry Zach, Addiego Elisa Cambronero, Mengistu Meron, Odorizzi Pamela M, Cai Yanhui, Jacobson Rachel, Wallin Jeffrey J
Abstract excerpt
Background: Selective and potent Toll-like receptor (TLR) agonists are currently under evaluation in preclinical models and clinical studies to understand how the innate immune system can be harnessed for therapeutic potential. These molecules are designed to modulate innate and adaptive immune responses, making them promising therapeutic candidates for treating diseases such as cancer or chronic viral...
Read the complete abstract on PubMedTopics
- Humans
- HIV Infections
- Leukocytes, Mononuclear
- Toll-Like Receptors