Article
ECPPF stratification identifies occult high-risk subgroups in stage I, grade 1 or 2, ≤50 % invasive endometrial cancer: Candidates for adjuvant therapy.
Gynecologic oncology - 1 May 2025
Gonzalez-Bosquet Jesus, Shahi Maryam, Yadav Siddhartha, Kanwar Nisha, Alvand Saba, Sosa Carlos, Dowdy Sean C, Halling Kevin C, Weroha S John, Bakkum-Gamez Jamie N, Podratz Karl C
Abstract excerpt
OBJECTIVE: To determine whether stratification with ECPPF (E2F1 + CCNA2 log2 expression and POLE, PPP2R1A, and FBXW7 variants) could identify occult cases of high-risk endometrial cancer (EC) in a traditionally low-risk cohort. METHODS: We identified 97 cases of clinicopathologic low-risk endometrioid EC (defined as stage I, grade 1 or 2, limited [≤50 %] myometrial invasion) from The Cancer Genome Atlas (TCGA)....
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