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Article

Assessing the Role of Rare Genetic Variation in Patients With Heart Failure.

JAMA cardiology - 1 Apr 2021

Povysil Gundula, Chazara Olympe, Carss Keren J, Deevi Sri V V, Wang Quanli, Armisen Javier, Paul Dirk S, Granger Christopher B, Kjekshus John, Aggarwal Vimla, Haefliger Carolina, Goldstein David B

Abstract excerpt

Importance: Sequencing studies have identified causal genetic variants for distinct subtypes of heart failure (HF) such as hypertrophic or dilated cardiomyopathy. However, the role of rare, high-impact variants in HF, for which ischemic heart disease is the leading cause, has not been systematically investigated. Objective: To assess the contribution of rare variants to all-cause HF with and without reduced left...

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Identifiers

PMID: 33326012
DOI: 10.1001/jamacardio.2020.6500
PMCID: PMC7745141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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