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Article

Increased preference for lysine over arginine in spike proteins of SARS-CoV-2 BA.2.86 variant and its daughter lineages.

PloS one - 1 Jan 2025

Božič Anže, Podgornik Rudolf

Abstract excerpt

The COVID-19 pandemic offered an unprecedented glimpse into the evolution of its causative virus, SARS-CoV-2. It has been estimated that since its outbreak in late 2019, the virus has explored all possible alternatives in terms of missense mutations for all sites of its polypeptide chain. Spike protein of the virus exhibits the largest sequence variation in particular, with many individual mutations impacting...

Read the complete abstract on PubMed

Topics

Spike Glycoprotein, Coronavirus
SARS-CoV-2
Lysine
Arginine
Humans
COVID-19
Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Amino Acid Sequence

Source

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Identifiers

PMID: 40193474
DOI: 10.1371/journal.pone.0320891
PMCID: PMC11975073

Provenance

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