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Article

Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis.

Journal of internal medicine - 1 Jun 2025

Sysojev Anton Öberg, Delcoigne Bénédicte, Frisell Thomas, Alfredsson Lars, Klareskog Lars, Saevarsdottir Saedis, Boman Magnus, Padyukov Leonid, Askling Johan, Westerlind Helga

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is the mainstay initial treatment of rheumatoid arthritis (RA), but individual response varies and remains difficult to predict. The role of genetics remains unclear, but studies suggest its importance. METHODS: Incident RA patients starting MTX-monotherapy were identified through a large-scale Swedish register linkage. Demographic, clinical, medical, and drug history features were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40190030
DOI: 10.1111/joim.20087
PMCID: PMC12087826

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