Article
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.
Nature communications - 23 Aug 2016
Sieberts Solveig K, Zhu Fan, García-García Javier, Stahl Eli, Pratap Abhishek, Pandey Gaurav, Pappas Dimitrios, Aguilar Daniel, Anton Bernat, Bonet Jaume, Eksi Ridvan, Fornés Oriol, Guney Emre, Li Hongdong, Marín Manuel Alejandro, Panwar Bharat, Planas-Iglesias Joan, Poglayen Daniel, Cui Jing, Falcao Andre O, Suver Christine, Hoff Bruce, Balagurusamy Venkat S K, Dillenberger Donna, Neto Elias Chaibub, Norman Thea, Aittokallio Tero, Ammad-Ud-Din Muhammad, Azencott Chloe-Agathe, Bellón Víctor, Boeva Valentina, Bunte Kerstin, Chheda Himanshu, Cheng Lu, Corander Jukka, Dumontier Michel, Goldenberg Anna, Gopalacharyulu Peddinti, Hajiloo Mohsen, Hidru Daniel, Jaiswal Alok, Kaski Samuel, Khalfaoui Beyrem, Khan Suleiman Ali, Kramer Eric R, Marttinen Pekka, Mezlini Aziz M, Molparia Bhuvan, Pirinen Matti, Saarela Janna, Samwald Matthias, Stoven Véronique, Tang Hao, Tang Jing, Torkamani Ali, Vert Jean-Phillipe, Wang Bo, Wang Tao, Wennerberg Krister, Wineinger Nathan E, Xiao Guanghua, Xie Yang, Yeung Rae, Zhan Xiaowei, Zhao Cheng, Greenberg Jeff, Kremer Joel, Michaud Kaleb, Barton Anne, Coenen Marieke, Mariette Xavier, Miceli Corinne, Shadick Nancy, Weinblatt Michael, de Vries Niek, Tak Paul P, Gerlag Danielle, Huizinga Tom W J, Kurreeman Fina, Allaart Cornelia F, Louis Bridges S, Criswell Lindsey, Moreland Larry, Klareskog Lars, Saevarsdottir Saedis, Padyukov Leonid, Gregersen Peter K, Friend Stephen, Plenge Robert, Stolovitzky Gustavo, Oliva Baldo, Guan Yuanfang, Mangravite Lara M
Abstract excerpt
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM...
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