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Article

Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis.

Rheumatology (Oxford, England) - 2 May 2024

Sysojev Anton Öberg, Saevarsdottir Saedis, Diaz-Gallo Lina-Marcela, Silberberg Gilad N, Alfredsson Lars, Klareskog Lars, Baecklund Eva, Björkman Lena, Kastbom Alf, Rantapää-Dahlqvist Solbritt, Turesson Carl, Jonsdottir Ingileif, Stefansson Kari, Frisell Thomas, Padyukov Leonid, Askling Johan, Westerlind Helga

Abstract excerpt

OBJECTIVES: To investigate the influence of genetic factors on persistence with treatment of early RA with MTX monotherapy. METHODS: We conducted a genome-wide association study (GWAS) in a sample of 3902 Swedish early-RA patients initiating MTX in DMARD monotherapy as their first-ever DMARD. The outcome, short- and long-term MTX treatment persistence, was defined as remaining on MTX at 1 and at 3 years,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37326842
DOI: 10.1093/rheumatology/kead301
PMCID: PMC11065441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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