Article
Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial.
The pharmacogenomics journal - 1 Feb 2014
Aslibekyan S, Brown E E, Reynolds R J, Redden D T, Morgan S, Baggott J E, Sha J, Moreland L W, O'Dell J R, Curtis J R, Mikuls T R, Bridges S L, Arnett D K
Abstract excerpt
Methotrexate (MTX) has emerged as first-line therapy for early moderate-to-severe rheumatoid arthritis (RA), but individual variation in treatment response remains unexplained. We tested the associations between 863 known pharmacogenetic variants and MTX response in 471 Treatment of Early Aggress...
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