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Article

Evaluation of a clinical pharmacogenetics model to predict methotrexate response in patients with rheumatoid arthritis.

The pharmacogenomics journal - 1 Jul 2018

López-Rodríguez Rosario, Ferreiro-Iglesias Aida, Lima Aurea, Bernardes Miguel, Pawlik Andrzej, Paradowska-Gorycka Agnieszka, Świerkot Jerzy, Slezak Ryszard, Gonzalez-Alvaro Isidoro, Narvaez Javier, Pérez-Pampín Eva, Mera-Varela Antonio, Vidal-Bralo Laura, Acuña-Ochoa José Gorgonio, Conde Carmen, Gonzalez Antonio

Abstract excerpt

Variability of response to treatment hinders successful management of rheumatoid arthritis (RA). Consequently, a clinical pharmacogenetics model for predicting response to methotrexate (CP-MTX) has been previously proposed that includes four clinical variables (disease activity, sex, the presence of rheumatoid factor and smoking status) and four SNPs (rs2236225, rs17602729, rs1127354, and rs2372536) in genes of...

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Share to Aged
Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid
Share to Cost-Benefit Analysis
Share to Drug Therapy, Combination
Share to Methotrexate
Share to Pharmacogenetics
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Source

Identifiers

PMID: 29520081
DOI: 10.1038/s41397-018-0017-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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