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Article

Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids

5 Apr 2025

Abstract excerpt

Abstract Trifluridine/Tipiracil (FTD/TPI, TAS102) has been approved for the treatment of patients with colorectal cancer (CRC) for its promising anticancer activity enabled by its incorporation into double strands during DNA synthesis. However, the mechanisms underlying the anticancer targets of FTD/TPI remain not fully understood. Here we report our observation of the activation of ferroptosis in CRC by FTD/TPI....

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Identifiers

PMID: 40188162
DOI: 10.1038/s41419-025-07541-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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