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LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis

25 Apr 2025

Abstract excerpt

BACKGROUND Radiotherapy is widely employed in colorectal cancer (CRC) treatment, but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure and recurrent metastasis. AIM To explore the role and underlying mechanism of the lncRNA FTX in radiotherapy resistance in CRC. METHODS LncRNA FTX expression in colorectal parent cells (HT29 and...

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PMID: 40308806
DOI: 10.3748/wjg.v31.i16.104305

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