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Targeting SLC3A2 Subunit of System XC- is Essential for m6A Reader YTHDC2 to be an Endogenous Ferroptosis Inducer in Lung Adenocarcinoma

2021-01-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>The<bold> </bold>m<sup>6</sup>A reader YT521-B homology containing 2 (YTHDC2) inhibits lung adenocarcinoma (LUAD) tumorigenesis by suppressing solute carrier 7A11 (SLC7A11)-dependent antioxidant function. SLC7A11 is a major functional subunit of system X<sub>C</sub><sup>-</sup>. Inhibition of system X<sub>C</sub><sup>-</sup> can induce ferroptosis. However, whet...

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Literature Corpus work
a51c57ea-a049-5e8e-a40c-dc47ad39e5d3
DOI
10.21203/rs.3.rs-152451/v1
Open publication

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Targeting SLC3A2 Subunit of System XC- is Essential for m6A Reader YTHDC2 to be an Endogenous Ferroptosis Inducer in Lung AdenocarcinomaDOI 10.21203/rs.3.rs-152451/v1
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