Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon.

Oncotarget - 4 Apr 2025

Sheehan Brock J, Edwards Bryson, Medrano Ivanna Soto, El-Saidi Mohammed A, Zaidan Wissam R, El-Ezzi Asmahan A, Kuddus Ruhul H

Abstract excerpt

The polymorphic genes PTGS1 and PTGS2 encode cyclooxygenases COX-1 and COX-2, respectively. Overexpression of these cyclooxygenases is linked to inflammation and neoplasms. This study investigated the potential association between the single nucleotide polymorphism (SNP) -842A>G (rs10306114) of the PTGS1 gene and SNP-765G>C (rs20417) of the PTGS2 gene with prostate cancer (PCa) and benign prostate hyperplasia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles
Share to Case-Control Studies
Share to Cyclooxygenase 1
Share to Cyclooxygenase 2
Share to Gene Frequency
Share to Genetic Association Studies
Share to Prostatic Hyperplasia
Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40184332
DOI: 10.18632/oncotarget.28710
PMCID: PMC11970937

Genes

PTGS1
PTGS2
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon.PMID 40184332Read ↗

Association between the 8473T>C polymorphism of PTGS2 and prostate cancer risk: a metaanalysis including 24,716 subjects.Semantic proximity Read ↗

Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer.Semantic proximity Read ↗

COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men.Semantic proximity Read ↗

Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.Semantic proximity Read ↗

Genetic variation in the COX-2 gene and the association with prostate cancer risk.Semantic proximity Read ↗

CCR2 and CCR5 genes polymorphisms in benign prostatic hyperplasia and prostate cancer.Semantic proximity Read ↗

Associations between variants in the cyclooxygenase 2 enzyme gene (PTGS2) and development of benign prostate enlargement.Semantic proximity Read ↗

Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians.Semantic proximity Read ↗

Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies.Semantic proximity Read ↗

[Genetic polymorphisms in benign prostatic hyperplasia: Progress in studies].Semantic proximity Read ↗

PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.Semantic proximity Read ↗

Lack of association between the cyclooxygenase 2 -765G>C polymorphism and prostate cancer risk: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.