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Article

PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.

Prostate cancer and prostatic diseases - 1 Jan 2009

Murad A, Lewis S J, Smith G Davey, Collin S M, Chen L, Hamdy F C, Neal D E, Donovan J, Martin R M

Abstract excerpt

Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found...

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Source

Identifiers

PMID: 19488068
DOI: 10.1038/pcan.2009.18

Genes

PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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