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Article

COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men.

Carcinogenesis - 1 Dec 2008

Fernandez Pedro, de Beer Pieter M, van der Merwe Lize, Heyns Chris F

Abstract excerpt

Cyclooxygenase-2 (COX-2) converts arachidonic acid to prostaglandins, which are important mediators of cell proliferation and inflammation. Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. We investigated the role of COX-2 variants in prostate cancer in a case-control study of South African Coloured men, consisting of 151 cases and 134 controls. The...

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Identifiers

PMID: 18974063
DOI: 10.1093/carcin/bgn245

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