Reference-Free Variant Calling with Local Graph Construction with ska lo (SKA).

Abstract excerpt

The study of genomic variants is increasingly important for public health surveillance of pathogens. Traditional variant-calling methods from whole-genome sequencing data rely on reference-based alignment, which can introduce biases and require significant computational resources. Alignment- and reference-free approaches offer an alternative by leveraging k-mer-based methods, but existing implementations often...

Topics

• Polymorphism, Single Nucleotide
• Algorithms
• Software
• Whole Genome Sequencing