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Article

Predicted functional consequences of WNT ligand mutations in colorectal cancer.

Biophysical journal - 6 May 2025

Ahmed Aamir, Shorthouse David

Abstract excerpt

Mutations to wingless integration site (WNT) ligands in cancer are poorly understood. WNT ligands are a family of secreted proteins that trigger the activation of the WNT pathway, with essential roles in cell development and carcinogenesis, particularly in the colorectal tract. While the structure of WNT ligands has been elucidated, little is known about how mutations in these proteins affect colorectal cancer....

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Topics

Colorectal Neoplasms
Humans
Ligands
Mutation
Molecular Dynamics Simulation
Wnt Proteins
Wnt-5a Protein

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Source

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Identifiers

PMID: 40165370
DOI: 10.1016/j.bpj.2025.03.030
PMCID: PMC12256883

Genes

WNT5A

Provenance

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