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Article

Mammographic density mediates the protective effect of early-life body size on breast cancer risk.

Nature communications - 13 May 2024

Vabistsevits Marina, Davey Smith George, Richardson Tom G, Richmond Rebecca C, Sieh Weiva, Rothstein Joseph H, Habel Laurel A, Alexeeff Stacey E, Lloyd-Lewis Bethan, Sanderson Eleanor

Abstract excerpt

The unexplained protective effect of childhood adiposity on breast cancer risk may be mediated via mammographic density (MD). Here, we investigate a complex relationship between adiposity in childhood and adulthood, puberty onset, MD phenotypes (dense area (DA), non-dense area (NDA), percent density (PD)), and their effects on breast cancer. We use Mendelian randomization (MR) and multivariable MR to estimate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38740751
DOI: 10.1038/s41467-024-48105-7
PMCID: PMC11091136

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