Article
Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk.
Nature communications - 9 Oct 2020
Sieh Weiva, Rothstein Joseph H, Klein Robert J, Alexeeff Stacey E, Sakoda Lori C, Jorgenson Eric, McBride Russell B, Graff Rebecca E, McGuire Valerie, Achacoso Ninah, Acton Luana, Liang Rhea Y, Lipson Jafi A, Rubin Daniel L, Yaffe Martin J, Easton Douglas F, Schaefer Catherine, Risch Neil, Whittemore Alice S, Habel Laurel A
Abstract excerpt
Mammographic density (MD) phenotypes are strongly associated with breast cancer risk and highly heritable. In this GWAS meta-analysis of 24,192 women, we identify 31 MD loci at P < 5 × 10-8, tripling the number known to 46. Seventeen identified MD loci also are associated with breast cancer risk in an independent meta-analysis (P < 0.05). Mendelian randomization analyses show that genetic estimates of dense area...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.