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Article

Role of Retroelements in Frontotemporal Dementia Development.

Frontiers in bioscience (Scholar edition) - 22 Jan 2025

Mustafin Rustam Nailevich

Abstract excerpt

Frontotemporal dementia (FTD) develops in proteinopathies involving TDP-43 (transactive response DNA-binding protein 43 kDa), tau, and FUS (fused in sarcoma) proteins, which possess antiviral properties and exert inhibitory effects on human transposable elements. Viruses and aging have been suggested to trigger FTD by activating specific retroelements. FTD is associated with multiple single nucleotide...

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Identifiers

PMID: 40150869
DOI: 10.31083/FBS25922

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FUS

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