Mitochondria-Rich Extracellular Vesicles From Bone Marrow Stem Cells Mitigate Muscle Degeneration in Rotator Cuff Tears in a Rat Model Through Macrophage M2 Phenotype Conversion.

doi:10.1016/j.arthro.2025.03.033

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mitochondria-Rich Extracellular Vesicles From Bone Marrow Stem Cells Mitigate Muscle Degeneration in Rotator Cuff Tears in a Rat Model Through Macrophage M2 Phenotype Conversion.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association - 1 Sept 2025

Gao Xing, Chen Yuanyuan, Wang Jingzeng, Xu Jian, Wan Hu, Li Xiao, Shi Yulong

Abstract excerpt

PURPOSE: To investigate the protective effects of extracellular vesicles derived from bone marrow stem cells (BMSC-EVs) on muscle degeneration in a rat model of rotator cuff tendon and suprascapular nerve (SSN) transection (termed the RCT-SSN model), focusing on mitochondrial transfer. METHODS: The EVs were identified and characterized. The RCT-SSN model was established by transecting the supraspinatus,...

Read the complete abstract on PubMed

Topics

Animals
Rotator Cuff Injuries
Extracellular Vesicles
Rats
Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophages

Rats, Sprague-Dawley

Mitochondria

Phenotype

Male

Muscular Atrophy

Mesenchymal Stem Cells

Rotator Cuff

Source

Open in PubMed

Identifiers

PMID: 40147598
DOI: 10.1016/j.arthro.2025.03.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 28 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria-Rich Extracellular Vesicles From Bone Marrow Stem Cells Mitigate Muscle Degeneration in Rotator Cuff Tears in a Rat Model Through Macrophage M2 Phenotype Conversion.PMID 40147598Read ↗

Small extracellular vesicles from mesenchymal stromal cells: the next therapeutic paradigm for musculoskeletal disordersSemantic proximity Read ↗

Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders.Semantic proximity Read ↗

Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cellsSemantic proximity Read ↗

Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Promotion of Tendon Repair - an Update of LiteratureSemantic proximity Read ↗

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Pro-Inflammatory Macrophage Polarization: Comparison of Matrix-Bound and Small Extracellular Vesicles.Semantic proximity Read ↗

Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophySemantic proximity Read ↗

Engineered Extracellular Vesicles Derived from Juvenile Mice Enhance Mitochondrial Function in the Aging Bone Microenvironment and Achieve RejuvenationSemantic proximity Read ↗

Extracellular Vesicles from Inflammation-Primed Adipose-Derived Stem Cells Enhance Achilles Tendon Repair by Reducing Inflammation and Promoting Intrinsic HealingSemantic proximity Read ↗

A “cell-free treatment” for tendon injuries: adipose stem cell-derived exosomesSemantic proximity Read ↗

Nanoscale Treatment of Intervertebral Disc Degeneration: Mesenchymal Stem Cell Exosome TransplantationSemantic proximity Read ↗

Spinal Cord Repair: From Cells and Tissue Engineering to Extracellular Vesicles.Semantic proximity Read ↗

Amniotic membrane-derived stromal cells release extracellular vesicles that favor regeneration of dystrophic skeletal musclesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.