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Article

A water-based mechanism of specificity and resistance for lapatinib with ErbB family kinases.

Biochemistry - 27 Mar 2012

Huang Yulin, Rizzo Robert C

Abstract excerpt

The dual kinase inhibitor lapatinib has a high affinity for EGFR and HER2 but a weak affinity for ErbB4, although the factors driving specificity for these highly homologous members of the ErbB family of receptor tyrosine kinases are not well understood. In this report, homology modeling, molecular dynamics simulations, and free energy calculations are employed with the goal of uncovering the energetic and...

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Identifiers

PMID: 22352796
DOI: 10.1021/bi2016553

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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