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Article

Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants.

PloS one - 1 Jan 2018

Verma Sharad, Goyal Sukriti, Kumari Anchala, Singh Aditi, Jamal Salma, Grover Abhinav

Abstract excerpt

HER-2 belongs to the human epidermal growth factor receptor (HER) family. Via different signal transduction pathways, HER-2 regulates normal cell proliferation, survival, and differentiation. Recently, it was reported that MCF10A, BT474, and MDA-MB-231 cells bearing the HER2 K753E mutation were resistant to lapatinib. Present study revealed that HER-2 mutant K753E showed some contrasting behaviour as compared to...

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Share to Drug Resistance, Neoplasm
Share to Lapatinib
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Protein Kinase Inhibitors

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Share to Receptor, ErbB-2

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Identifiers

PMID: 29389942
DOI: 10.1371/journal.pone.0190942
PMCID: PMC5794075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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