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Fibroblast-derived osteoglycin promotes epithelial cell repair

25 Mar 2025

Abstract excerpt

There is an urgent need for innovative therapies targeting defective epithelial repair in chronic diseases like COPD. The mesenchymal niche is a critical regulator in epithelial stem cell activation, suggesting that their secreted factors are possible potent drug targets. Utilizing a proteomics-guided drug discovery strategy, we explored the lung fibroblast secretome to uncover impactful drug targets. Our lung...

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PMID: 40133363
DOI: 10.1038/s41536-025-00404-3

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