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Article

circKCNQ5 promotes the proliferation of DNA-methyltransferase 3A R882 mutated acute myeloid leukemia cells by elevating high-mobility group box 1 expression.

Annals of medicine - 1 Dec 2025

Chen Yijian, Zhu Xiaodan, Lin Chuanming, Xu Rong, Xu Pengxiang, Xin Liuyan, Li Lin, Zhang Liqun

Abstract excerpt

BACKGROUND: Patients with acute myeloid leukemia (AML) harboring the DNA-methyltransferase 3 A (DNMT3A) R882 mutation (DR882MUT) usually have a high recurrence rate and poor prognosis. circKCNQ5 levels were aberrantly elevated in patients with AML according to the microarray platform. Therefore, the purpose of this study is to investigate the effect and mechanism of circKCNQ5 on DR882MUT AML cell proliferation....

Read the complete abstract on PubMed

Topics

Humans
Leukemia, Myeloid, Acute
DNA Methyltransferase 3A
Cell Proliferation
DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HMGB1 Protein

Mutation

Cell Line, Tumor

RNA, Circular

HL-60 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 40130394
DOI: 10.1080/07853890.2025.2478309
PMCID: PMC11938305

Genes

HMGB1
DNMT3A
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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