Article
Detection of KRAS mutations in circulating tumour DNA from plasma and urine of patients with colorectal cancer.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Dec 2021
Ohta Ryo, Yamada Takeshi, Sonoda Hiromichi, Matsuda Akihisa, Shinji Seiichi, Takahashi Goro, Iwai Takuma, Takeda Kohki, Ueda Koji, Kuriyama Sho, Miyasaka Toshimitsu, Yokoyama Yasuyuki, Hara Keisuke, Yoshida Hiroshi
Abstract excerpt
BACKGROUND: Circulating tumour DNA (ctDNA) is very useful for purposes of cancer genetics; however, it has some limitations. Recently, ctDNA in body fluids, such as urine, sputum, and pleural effusion, has been investigated. The aim of this study was to evaluate the quantity of ctDNA derived from urine (trans-renal ctDNA) and the accuracy of KRAS mutation detection in relation to disease stage in colorectal...
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