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Exact calculation of the expected SFS in structured populations.

Theoretical population biology - 1 Jun 2025

Arredondo Armando, Corujo Josué, Noûs Camille, Boitard Simon, Chikhi Lounès, Mazet Olivier

Abstract excerpt

The Site Frequency Spectrum (SFS), summary statistic of the distribution of derived allele frequencies in a sample of DNA sequences, provides information about genetic variation and can be used to make population inferences. The exact calculation of the expected SFS in a panmictic population under the infinite-site model of mutation has been known in the Markovian coalescent theory for decades, but its...

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PMID: 40122298
DOI: 10.1016/j.tpb.2025.03.003

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