Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation.

doi:10.1186/s12933-025-02683-y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation.

Cardiovascular diabetology - 20 Mar 2025

Di Giacomo Barbagallo Francesco, Bosco Giosiana, Di Marco Maurizio, Scilletta Sabrina, Miano Nicoletta, Musmeci Marco, Martedì Marina, González-Lleó Ana M, Ibarretxe Daiana, De Francesco Ernestina Marianna, Malaguarnera Roberta, Di Pino Antonino, Masana Luís, Purrello Francesco, Piro Salvatore, Scicali Roberto

Abstract excerpt

BACKGROUND: Familial hypercholesterolemia (FH) is a genetic condition characterized by elevated LDL-C and increased cardiovascular risk. Beyond LDL-C levels, the impact of genotype on glucose homeostasis has not been well evaluated. We aimed to evaluate the impact of genotype on glycemic status and on atherosclerotic injury in FH subjects. METHODS: We conducted a cross-sectional study on 322 FH subjects not on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asymptomatic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Atherosclerosis

Share to Blood Glucose

Share to Cholesterol, LDL

Share to Hyperlipoproteinemia Type II

Share to Plaque, Atherosclerotic

Share to Receptors, LDL

Share to Vascular Calcification

Source

Open in PubMed Open full text

Identifiers

PMID: 40114220
DOI: 10.1186/s12933-025-02683-y
PMCID: PMC11927314

Genes

LDLR
FH
HGS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation.PMID 40114220Read ↗

Clinical Aspects of Genetic and Non-Genetic Cardiovascular Risk Factors in Familial HypercholesterolemiaSemantic proximity Read ↗

Why patients with familial hypercholesterolemia are at high cardiovascular risk? Beyond LDL-C levels.Semantic proximity Read ↗

From Phenotype to Genotype and Beyond: Insights into Familial Hypercholesterolemia and Familial Hypertriglyceridemia.Semantic proximity Read ↗

Cardiovascular risk factor profiles in familial hypercholesterolemia patients with and without genetic mutation compared to a nationally representative sample of adults in a high-risk European country.Semantic proximity Read ↗

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.Semantic proximity Read ↗

Clinical Perspectives of Genetic Analyses on Dyslipidemia and Coronary Artery DiseaseSemantic proximity Read ↗

Discriminative ability of LDL-cholesterol to identify patients with familial hypercholesterolemia: a cross-sectional study in 26,406 individuals tested for genetic FH.Semantic proximity Read ↗

Genotype-guided diagnosis in familial hypercholesterolemia: clinical management and concerns.Semantic proximity Read ↗

Diabetes and Familial Hypercholesterolemia: Interplay between Lipid and Glucose Metabolism.Semantic proximity Read ↗

Characteristics of Genetically Confirmed Familial Hypercholesterolemia in Chinese Patients with Coronary Heart DiseaseSemantic proximity Read ↗

Phenotype vs. genotype in severe familial hypercholesterolemia: what matters most for the clinician?Semantic proximity Read ↗

Clinical, Anthropometric and Biochemical Characteristics of Patients with or without Genetically Confirmed Familial Hypercholesterolemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.