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Article

Discriminative ability of LDL-cholesterol to identify patients with familial hypercholesterolemia: a cross-sectional study in 26,406 individuals tested for genetic FH.

Circulation. Cardiovascular genetics - 1 Jun 2012

Huijgen Roeland, Hutten Barbara A, Kindt Iris, Vissers Maud N, Kastelein John J P

Abstract excerpt

BACKGROUND: Screening for familial hypercholesterolemia (FH) within affected families is often based on cutoff values for low-density lipoprotein cholesterol (LDL-C). However, the diagnostic accuracy of LDL-C levels is influenced by the magnitude of the LDL-C overlap between FH patients and unaffected relatives. The purpose of the current study was to assess to what extent this overlap is influenced by the...

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Identifiers

PMID: 22553281
DOI: 10.1161/CIRCGENETICS.111.962456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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