Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.

Genes - 21 Jun 2026

Ferrandino Martina, Cerrato Ylenia, Iannuzzo Gabriella, Calcaterra Ilenia Lorenza, Di Minno Matteo Nicola Dario, Fortunato Giuliana, Di Taranto Maria Donata

Abstract excerpt

High levels of low-density lipoprotein cholesterol (LDL-c) have been recognized as the main causal factor of atherosclerotic cardiovascular disease (ASCVD) and are influenced by both genetic and environmental factors. Among genetic determinants, Familial Hypercholesterolemia (FH) is the most common monogenic disorder, caused by rare high-impact variants in genes involved in LDL uptake. Other monogenic causes of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, LDL
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Hypercholesterolemia

Share to Lipoprotein(a)

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42353880
DOI: 10.3390/genes17060721
PMCID: PMC13299752

Genes

FH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.PMID 42353880Read ↗

The clinical applicability of polygenic risk scores for LDL-cholesterol: considerations, current evidence and future perspectivesSemantic proximity Read ↗

Polygenic contribution for familial hypercholesterolemia (FH).Semantic proximity Read ↗

Polygenic Contribution to Low-Density Lipoprotein Cholesterol Levels and Cardiovascular Risk in Monogenic Familial Hypercholesterolemia.Semantic proximity Read ↗

Update on genetics of familial hypercholesterolemia.Semantic proximity Read ↗

Clinical Aspects of Genetic and Non-Genetic Cardiovascular Risk Factors in Familial HypercholesterolemiaSemantic proximity Read ↗

Single Nucleotide Variants Associated With Polygenic Hypercholesterolemia in Families Diagnosed Clinically With Familial Hypercholesterolemia.Semantic proximity Read ↗

Polygenic Hypercholesterolemia and Cardiovascular Disease RiskSemantic proximity Read ↗

Clinical utility of the polygenic LDL-C SNP score in familial hypercholesterolemiaSemantic proximity Read ↗

Why patients with familial hypercholesterolemia are at high cardiovascular risk? Beyond LDL-C levels.Semantic proximity Read ↗

The familial hypercholesterolaemia phenotype: Monogenic familial hypercholesterolaemia, polygenic hypercholesterolaemia and other causes.Semantic proximity Read ↗

An 8-SNP LDL Cholesterol Polygenic Score: Associations with Cardiovascular Risk Traits, Familial Hypercholesterolemia Phenotype, and Premature Coronary Heart Disease in Central Romania.Semantic proximity Read ↗

Improved Genetic Characterization of Hypercholesterolemia in Latvian Patients with Familial Hypercholesterolemia: A Combined Monogenic and Polygenic Approach Using Whole-Genome Sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.