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Article

Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity

20 Mar 2025

Abstract excerpt

Histone H3 lysine 9 dimethylation and trimethylation (H3K9me2/3) are prevalent in human genomes, especially in heterochromatin and specific euchromatic genes. Methylation of H3K9 is modulated by enzymes such as SUV39H1, SUV39H2, SETDB1, SETDB2, and EHMT1/2, which influence cancer progression. This study reveals differential expression of these six H3K9 methyltransferases in tumors, with SUV39H1, SUV39H2, and...

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PMID: 40113969
DOI: 10.1038/s41698-025-00829-5

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