T cell receptor precision editing of regulatory T cells for celiac disease

Abstract excerpt

Celiac disease, a gluten-sensitive enteropathy, demonstrates a strong human leukocyte antigen (HLA) association, with more than 90% of patients carrying the HLA-DQ2.5 allotype. No therapy is available for the condition except for a lifelong gluten-free diet. To address this gap, we explored the therapeutic potential of regulatory T cells (T regs ). By orthotopic replacement of T cell receptors (TCRs) through...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Celiac Disease Research and Management
• Share to T-cell and B-cell Immunology