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Article

Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score.

JAMA network open - 3 Mar 2025

Kwon Dayoon, Paul Kimberly C, Kusters Cynthia, Wu Jun, Bronstein Jeff M, Lill Christina M, Ketzel Matthias, Raachou-Nielsen Ole, Hansen Johnni, Ritz Beate

Abstract excerpt

Importance: Genetic and environmental factors are linked to Parkinson disease (PD), but the role of genetic susceptibility in the association between traffic-related air pollution (TRAP) and PD remains unclear. Objective: To assess the gene-environment interaction between the polygenic risk score (PRS) for PD and long-term TRAP exposure and to estimate the joint effect with PD risk. Design, Setting, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40094665
DOI: 10.1001/jamanetworkopen.2025.0854
PMCID: PMC11915066

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