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USP7 V517F mutation as a mechanism of inhibitor resistance

14 Mar 2025

Abstract excerpt

Anticipating and addressing resistance is essential for maximizing the potential of an oncology target and effectively addressing clinical needs. In this study, we aimed to proactively outline the resistance mechanisms of USP7 inhibitors. We discovered a key treatment-emergent heterozygous mutation (V517F) in USP7 in the binding pocket of compounds as the primary cause of resistance to the USP7 inhibitor...

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PMID: 40087304
DOI: 10.1038/s41467-025-56981-w

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