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Article

Discovering new biology with drug-resistance alleles.

Nature chemical biology - 1 Dec 2021

Freedy Allyson M, Liau Brian B

Abstract excerpt

Small molecule drugs form the backbone of modern medicine's therapeutic arsenal. Often less appreciated is the role that small molecules have had in advancing basic biology. In this Review, we highlight how resistance mutations have unlocked the potential of small molecule chemical probes to discover new biology. We describe key instances in which resistance mutations and related genetic variants yielded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34799733
DOI: 10.1038/s41589-021-00865-9
PMCID: PMC9530778

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