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Article

Direct evidence for systems-level modulation of initial drug (in)sensitivity in rats.

Psychopharmacology - 1 Apr 2007

Kaiyala Karl J, Butt Shezhad, Ramsay Douglas S

Abstract excerpt

RATIONALE: Some argue that pharmacological effects trigger corrective regulatory responses of varying strength. If so, some commonly used in vivo measures of initial drug sensitivity are difficult to interpret because the measured effects represent a combination of underlying pharmacological effects and regulatory counter-responses with the relative contribution of each influenced by individual and dose-related...

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Source

Identifiers

PMID: 17237917
DOI: 10.1007/s00213-006-0657-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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